Nhu Pham Plant Biology Graduate Student Nhu Pham joined the Lin lab in 2018 as a Research Professional and in 2021 she joins the lab as a Graduate Student. Her work interests are in the emergence pathogen, Aspergillus fumigatus, and Cryptococcus neoformans. Her work in A. fumigatus mainly focuses on the pathogen’s secondary metabolite, melanin. She hopes to grasp the trafficking pathway of the palmitoylated melanin enzymes. Nhu's current thesis work involves the intercellular communication that triggers biofilm formation in Cryptococcus neoformans. She wants to identify the unknown signal as well as to characterize the signal pathways. There has been a lack of knowledge on the role of biofilm in Basidiomycetes and she would like to uncover the importance of this morphology. In addition, she focuses on vaccine discovery, virulence pathways, and immunological mechanisms in Cryptococcus neoformans. With this work, she intends to achieve a better understanding of these two pathogenic organisms to unravel the mechanisms of these pathogens' behaviors. Research Labs (via personnel): Xiaorong Lin Labs: Lin Lab Selected Publications Selected Publications: Pham T*, Shi R*, Ambati S*, Meagher R, and Lin X (2024) All hands on Dect: Treating Cryptococcosis with DectiSomes. iScience *co-first authors Li Y, Chadwick B, Pham T, Xie X, Lin X, (2024) Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen Cryptococcus neoformans. mBio Pham T*, Li Y*, Watford W, Lin X (2023) Vaccination with a ZNF2oe strain provides long-lasting protection against cryptococcosis and is effective in immunocompromised hosts. Infection and Immunity, 91(7):e0019823; DOI: 10.1128/iai.00198-23 *co-first authors Chadwick B, Pham T, Xie X, Ristow L, Krysan D, Lin X (2022) The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans. eLife, 11:e82563; DOI: 10.7554/eLife.82563 Li Y, Pham T, Xie X, Lin X (2022) Identification and Characterization of an Intergenic “Safe Haven” Region in Human Fungal Pathogen Cryptococcus gattii. Journal of Fungi, 8(2), 178; DOI: 10.3390/jof8020178 Lin J, Pham T, Hipsher K, Glueck N, Fan Y, Lin X, (2022) Immunoprotection against Cryptococcosis Offered by Znf2 Depends on Capsule and the Hyphal Morphology. mBio, DOI: 10.1128/mbio.02785-21 Strycker BD, Han Z, Bahari A, Pham T, Lin X, Shaw B, Sokolov AV, O Scully M. (2021) Raman Characterization of Fungal DHN and DOPA Melanin Biosynthesis Pathways. Journal of Fungi, 7(10), 841. DOI: 10.3390/jof7100841 Ambati S, Pham T, Lewis Z, Lin X, and Meagher R. (2021) DC-SIGN targets amphotericin D-loaded liposomes to diverse pathogenic fungi. Fungal Biology and Biotechnology, 8(1), 1-13. DOI: 10.1186/s40694-021-00126-3 Ambati S, Pham T, Lewis Z, Lin X, and Meagher R. (2021) DectiSomes: Glycan Targeting of Liposomal Drugs Improves the Treatment of Disseminated Candidiasis. Antimicrobial Agents and Chemotherapy, 01467-21. DOI: 10.1128/AAC.01467-21 Ambati S, Ellis E, Pham T, Lewis Z, Lin X, and Meagher R. (2021) Antifungal-Liposomes Directed by Dectin-2 Offer a Promising Therapeutic Option for Pulmonary Aspergillosis. mBio, 12 (1), e00030-21. DOI: 10.1128/mBio.00030-21 Pham T, Xie X, and Lin X. (2020). An intergenic “safe haven” region in Aspergillus fumigatus. Medical Mycology, 58, 1178–1186. DOI: 10.1093/mmy/myaa009. PMID: 32171003 Read more about Nhu Pham
Phosphate-Dependent Regulation in the Methane-Producing Archaeon Methanococcus maripaludis Phosphate-Dependent Regulation in the Methane-Producing Archaeon Methanococcus maripaludis Friday, November 19 2021, 2pm 404D, Biological Sciences Type of Event: Student Seminars Taiwo Akinyemi Whitman Laboratory UGA Deptartment of Microbiology Read more about Phosphate-Dependent Regulation in the Methane-Producing Archaeon Methanococcus maripaludis
Expanding our current understanding of vitamin B6 metabolism in Salmonella enterica Expanding our current understanding of vitamin B6 metabolism in Salmonella enterica Thursday, November 11 2021, 1pm Online Via Zoom Type of Event: Student Seminars Huong Vu Downs Laboratory UGA Department of Microbiology Read more about Expanding our current understanding of vitamin B6 metabolism in Salmonella enterica
The role of N-terminal acetylation in modulation of S. enterica physiology The role of N-terminal acetylation in modulation of S. enterica physiology Tuesday, November 9 2021, 1pm Online Via Zoom Special Information: See department email for link and password Type of Event: Student Seminars Anastacia Parks Escalante Laboratory UGA Department of Microbiology Read more about The role of N-terminal acetylation in modulation of S. enterica physiology
Exploring cooperative nutrient dynamics that support marine microbial interactions Thursday, November 18 2021, 11:10am Room 404D Biological Sciences Building Type of Event: Department Seminars Dr. Bryn Durham Department of Biology University of Florida Durham Lab A Special Alumni Seminar hosted by MGSA: Jack Payne Alumni Seminar Graduate student recipient of the "Dr. William Jackson and Jane Payne Graduate Fellowship in Microbiology" will be announced. Read more about Exploring cooperative nutrient dynamics that support marine microbial interactions
Towards developing an academic career in the biomedical sciences Thursday, October 28 2021, 11:10am Room 404D Biological Sciences Building Type of Event: Department Seminars Dr. Rob Onyenwoke Biomanufacturing Research Institute and Technology Enterprise North Carolina Central University NCCU Research Special seminar in honor of Dr. Juergen Wiegel. Graduate student awardee will be announced Read more about Towards developing an academic career in the biomedical sciences
Bacterial microcompartments (BMCs): Metabolic Organelles of Bacteria Thursday, December 2 2021, 11:10am Room 404D Biological Sciences Building Type of Event: Department Seminars Dr. Cheryl Kerfeld Michigan State University and Lawrence Berkeley National Laboratory Kerfeld Lab Special Seminar in honor of Dr. Joy Porter Williams. Graduate student awardee will be announced. Read more about Bacterial microcompartments (BMCs): Metabolic Organelles of Bacteria
Helicobacter pylori genetic diversity and gastric cancer risk Thursday, November 11 2021, 11:10am Online via Zoom Special Information: see departmental email for zoom link Type of Event: Department Seminars Dr. Timothy Cover Department of Pathology, Microbiology and Immunology Vanderbilt University Dr. Timothy Cover Read more about Helicobacter pylori genetic diversity and gastric cancer risk
Tripping on your own cloak: How fungal cell wall repair pathways can expose ß(1,3)-glucan to the host immune system Thursday, November 4 2021, 11:10am Room 404D Biological Sciences Building Type of Event: Department Seminars Dr. Todd Reynolds Department of Microbiology University of Tennessee Dr. Todd Reynolds Read more about Tripping on your own cloak: How fungal cell wall repair pathways can expose ß(1,3)-glucan to the host immune system