Postdoctoral Research Associate Yeqi joined the Lin lab in 2021 as a postdoctoral associate. He received a Ph.D degree from the Nanjing Normal University. His previous work mainly focuses on the drug resistance in Aspergillus fumigatus. Now his project involves in how the cryptococcus promotes host protective immune response. He is exploring which antigens presented in the cryptococcal cells and how to use these antigens or filamentous strains as vaccine candidates. With these works, he hopes to unravel the molecular mechanisms of antigens providing the protective effect. Research Labs (via personnel): Xiaorong Lin Labs: Lin Lab Selected Publications Selected Publications: 1.Li Y, Chadwick B, Pham T, Xie X, Lin X. Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen Cryptococcus neoformans. mBio 2024 May 14:e0092024. 2. Pham T#, Li Y#, Watford W, Lin X. Vaccination with a ZNF2oe strain provides long-lasting protection against cryptococcosis and is effective in immunocompromised hosts. Infect Immun 2023 Jul 18;91(7):e0019823.. 3. Li Y, Dai M, Lu L, Zhang Y. The C2H2-Type Transcription Factor ZfpA, Coordinately with CrzA, Affects Azole Susceptibility by Regulating the Multidrug Transporter Gene atrF in Aspergillus fumigatus. Microbiol Spectr. 2023 Jun 15;e0032523. 4. Li Y, Pham T, Xie X, Lin X. Identification and characterization of an intergenic “safe haven” region in human fungal pathogen Cryptococcus gattii. J. Fungi 2022, 8, 178. 5. Li Y, Dai M, Zhang Y, Lu L. The sterol C-14 reductase Erg24 is responsible for ergosterol biosynthesis and ion homeostasis in Aspergillus fumigatus. Applied Microbiology and Biotechnology. 2021 Feb;105(3):1253-1268. 6. Li Y, Zhang Y, Zhang C, Wang H, Wei X, Chen P, Lu L. Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1711-1721. 7. Li Y, Zhang Y, Lu L. Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus. Med Mycol. 2019 Apr 1;57 (Supplement_2): S233-S238.
