We use the easy genetic system of a soil bacterium, Acinetobacter baylyi ADP1, to study diverse aspects of gene expression and chromosomal rearrangements. This research has implications for medical issues (gene amplification), environmental issues (bioremediation), biotechnology/bioenergy (conversion of lignin to biofuels), and evolution (new methods for experimental evolution).
Elliott, K.T., Cuff, L.E., and Neidle, E.L. (2013) Copy number change: evolving views on gene amplification. Future Microbiology 8:887-899.
Alanazi, A.M., Neidle, E.L., and Momany, C. (2013) The DNA-binding domain of BenM reveals the structural basis for the recognition of a T-N11-A sequence motif by LysR-type transcriptional regulators. Acta Crystallographica Section D-Biological Crystallography 69:1995-2007.
Seaton, S.C., Elliott, K.T., Cuff, L.E., Laniohan, N.S., Patel, P.R., and Neidle, E.L. (2012) Genome-wide selection for increased copy number in Acinetobacter baylyi ADP1: locus and context-dependent variation in gene amplification. Molecular Microbiology 83:520-535.