TitleSense and sensibility: flagellum-mediated gene regulation.
Publication TypeJournal Article
Year of Publication2010
AuthorsAnderson, JK, Smith, TG, Hoover, TR
JournalTrends Microbiol
Date Published2010 Jan
KeywordsBacterial Proteins, Caulobacter crescentus, Epsilonproteobacteria, Flagella, Gene Expression Regulation, Bacterial, Salmonella typhimurium, Sigma Factor

The flagellum, a rotary engine required for motility in many bacteria, plays key roles in gene expression. It has been known for some time that flagellar substructures serve as checkpoints that coordinate flagellar gene expression with assembly. Less well understood, however, are other more global effects on gene expression. For instance, the flagellum acts as a 'wetness' sensor in Salmonella typhimurium, and as a mechanosensor in other bacteria. Additionally, it has been implicated in a variety of bacterial processes, including biofilm formation, pathogenesis and symbiosis. Although for many of these processes it might be simply that motility is required, in other cases it seems that the flagellum plays an underappreciated role in regulating gene expression.

Alternate JournalTrends Microbiol.
PubMed ID19942438
Department Authors: 
Timothy Hoover
Lab Association: