Research Professional III

Contact Info

Rm 204 Biological Sciences Building

Srijana Upadhyay joined the Lin lab in 2010. She obtained her Master’s degree in Vegetable Science and Bachelor degree in Agriculture from the Himachal Pradesh Krishi Vishvavidyalaya, India. After finishing her Master’s, she worked in Nepal Agriculture Research council for a year where she was involved in tomato hybrid seed production program. There she helped to develop different inbred lines and hybrids of tomato. From 2002-2003 she worked as a vegetable breeder for Nepal SEAN Seed Company. She moved from Nepal to US in 2003. From 2003-2010 she had been working in the Department of Plant Pathology and Microbiology at Texas A&M University, where the research focused on fungal developmental biology. She was mainly involved in the study of developmental biology and genetics of Aspergillus nidulans and evolution of asexual sporulation in filamentous fungi. After joining the Lin lab in 2010, Srijana is working on the discovery and characterization of novel developmentally regulated genes that are critical for fungal virulence. 

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Labs (via personnel):
Selected Publications:

Rachana Gyawali, Youbao Zhao, Jianfeng Lin, Yumeng Fan, Xinping Xu, Srijana Upadhyay, and Xiaorong Lin. 2017. Pheromone independent unisexual development in Cryptococcus neoformans. PLoS Genet. 2017 May; 13(5)

Gyawali R, Upadhyay S, Way J and Lin X. 2017. A Family of secretory proteins is associated with different morphotypes in Cryptococcus neoformans. Appl Environ Microbiol. 2017 Feb 15;83(5)

Upadhyay S, Xu X and Lin X. 2016. Interactions between melanin enzymes and their atypical recruitment to the secretory pathway by palmitoylation. MBio. 2016 Nov 22;7(6)

Upadhyay S, Xu X, Lowry D, Jackson JC, Roberson RW and Lin X. 2016. Subcellular compartmentalization and trafficking of the biosynthetic machinery for fungal melanin. Cell Rep. 2016 Mar 22;14(11):2511-8.

Zhai B, Wozniak KL, Masso-Silva J, Upadhyay S, Hole C, Rivera A, Wormley FL Jr and Lin X. 2015. Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants. MBio. 2015 Oct 6;6(5):e01433-15.

Chung D, Upadhyay S, Bomer B, Wilkinson HH, Ebbole DJ and Shaw BD. 2015. Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants. Mycologia. 2015 Mar-Apr;107(2):298-306.

Wang L, Tian X, Gyawali R, Upadhyay S, Foyle D, Wang G, Cai JJ and Lin X. 2014. Morphotype transition and sexual reproduction are genetically associated in a ubiquitous environmental pathogen. PLoS Pathog. 2014 Jun 5;10(6

Upadhyay S, Torres G and Lin X. 2013. Laccases involved in 1,8-dihydroxynaphthalene melanin biosynthesis in Aspergillus fumigatus are regulated by developmental factors and copper homeostasis. Eukaryot Cell. 2013 Dec;12(12):1641-52.

Zhai B, Zhu P, Foyle D, Upadhyay S, Idnurm A and Lin X. 2013. Congenic strains of the filamentous form of Cryptococcus neoformans for studies of fungal morphogenesis and virulence. Infect Immun. 2013 Jul;81(7):2626-37.

B. D. Shaw, D.W. Chung, C. L. Wang; L. A. Quintanilla and S. Upadhyay. 2011. A role for endocytic cycling in hyphal growth. Fungal Biology 115: 541-546.

D.-W. Chung, C. Greenwald, S. Upadhyay, S. Ding, H. H. Wilkinson, D. J. Ebbole, and B. D. Shaw. 2011. acon-3, the Neurospora crassa ortholog of the developmental modifier, medA, complements the conidiation defect of the Aspergillus nidulans mutant. Fungal Genetics and Biology  48: 370-376

S. Upadhyay, and B. D. Shaw. 2008. The Role of actin, fimbrin, and endocytosis in growth of hyphae in Aspergillus nidulans.  Molecular Microbiology 68: 690-705.

S. Upadhyay, and B. D. Shaw.  2006.  A phosphoglucose isomerase mutant in Aspergillus nidulans is defective in hyphal polarity and conidiation.  Fungal Genetics and Biology 43: 739-751. (Includes Cover Image)

B. D. Shaw and S. Upadhyay. 2005. Aspergillus nidulans swoK encodes an RNA binding protein that is important for cell polarity. Fungal Genetics and Biology 42: 862-872.